Based on type of microstructure and the original model of structure, we can select suitable structure genome (SG) to perform the predictions of effective properties of composite laminates. This cane be either the predictions of ABD matrix or 3D effective properties of composite laminates. Let the material properties a Lamina be: AS4 3501-6 E,,11,,=126 GPA, E,,22,,=11 GPA, v,,12,,=0.28, v,,23,,=0.4, G,,12,,=6.6GPa The laminate lay-up: [0/90/±45],,2s,,